I cite this study to support my thoughts concerning CoQ10 supplementation by those currently taking or proposing to take statin drugs of any kind. This content does not have an Arabic version. Because coenzyme Q10 plays a role in muscle cell energy production, some researchers have proposed that taking a coenzyme Q10 supplement might reduce the risk of muscle-related side effects. National Center for Complementary and Integrative Health. COQ10 Dosage. Can coenzyme Q10 prevent statin side effects? Advertising revenue supports our not-for-profit mission. Parkinson's disease. Newsletter: Mayo Clinic Health Letter — Digital Edition, Book: Mayo Clinic Family Health Book, 5th Edition. It occurs when muscle cells break down. Study results of the benefits of CoQ10 for reducing muscle pain associated with statin use are conflicting, however. In a study published in the American Journal of Cardiology, researchers indicate that using CoQ10 supplements seemed to decrease the muscle breakdown, pain, and discomfort of people taking statins. Statins have been found to reduce the amount of naturally occurring coenzyme Q10 in the body. Research on CoQ10 use for specific conditions and activities shows: 1. https://naturalmedicines.therapeuticresearch.com. Because coenzyme Q10 plays a role in muscle cell energy production, some researchers have proposed that taking a coenzyme Q10 supplement might reduce the risk of muscle-related side effects. CoQ10 supplements can interact with some medications, including beta-blockers, some antidepressants, and chemotherapy drugs. Some research suggests coenzyme Q10 may help reduce muscle pain and weakness as a side effect of statin use. Mayo Clinic. Coenzyme Q10, or CoQ10, is a substance that the human body makes naturally. People with certain conditions, including diabetes, Parkinson’s disease, and heart problems, tend to have low levels of CoQ10. New drugs used alongside statins can lower LDL cholesterol to really low levels, but do the risks outweigh the benefits? Statins can cause side effects such as: Some people experience more serious problems, including a condition known as rhabdomyolysis. This content does not have an English version. Arcus senilis: A sign of high cholesterol? Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Muscle aches are a common side effect of statins, and CoQ10 is important for muscle function, so scientists have wondered if raising blood levels of CoQ10 might relieve the aches. However, the evidence is inconclusive. Your doctor might also decrease the dose of your statin, try a different statin or switch you to a different type of cholesterol-lowering medication entirely. However, a recent study in Atherosclerosis suggests that CoQ10 does not improve muscle pain in people taking statins. After a flood, are food and medicines safe to use? It isn’t known if disease causes the deficiency or if the deficiency appears first, causing cells to age faster and making disease more likely. Effects of coenzyme Q10 on statin-induced myopathy: An updated meta-analysis of randomized controlled trials. Mayo Clinic does not endorse companies or products. Hypothyroidism: Can calcium supplements interfere with treatment? However, a recent study in Atherosclerosis suggests that CoQ10 does not improve muscle pain in people taking statins. Lopez-Jimenez F (expert opinion). CoQ10 has also been studied as a preventive treatment for migraine headaches, though it may take several months to work. Taking a statin to lower "bad" LDL cholesterol also lowers CoQ10, a naturally occurring chemical in the body involved in energy production in cells. While it was once thought that CoQ10 could improve blood pressure, a recent review published in the Cochrane Library suggests that CoQ10 does not decrease blood pressure any more than placebo does. Some research also suggests that when combined with other nutrients, CoQ10 might aid recovery in people who've had bypass and heart valve surgeries. The new study also compared the effects of different types of statins on CoQ10, and these results are surprising. Cholesterol is a fatty substance that’s needed to build cells. Pomegranate juice: Can it lower cholesterol? Last medically reviewed on October 10, 2016. Because coenzyme Q10 doesn't cause side effects for most people, your doctor might suggest a trial of it to see if it helps. To play it safe, it may be best to take statins at least a couple of hours before consuming a green tea supplement or beverage. https://www.uptodate.com/contents/search. Treatment with statins has been associated with reduced plasma CoQ10 levels, and it has been hypothesised that supplementation with CoQ10 may assist with management of statin … Although CoQ10 supplements seems to show much promise for heart health, their effectiveness for improving muscle pain from statins is unclear. Every cell in the body needs coenzyme Q10 to help generate energy. Although statins are very effective, they’re not for everybody. 2. While there aren’t enough studies to confirm how well it works to do this, it may be possible to combine CoQ10 with statins for better results. Make sure you consult your doctor before taking CoQ10. Additional research is needed to confirm this effect. How Much Cholesterol Should I Be Having Each Day to Be Healthy? Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. Most importantly, studies which evaluate the effect of CoQ10 in improving adherence to statins are currently lacking which is why NICE do not recommend its use. It was also be… Hypothyroidism symptoms: Can hypothyroidism cause eye problems? 2018; doi:10.1007/s13311-018-0670-z. As muscles collapse, a certain protein is released into the bloodstream. While there arent enough studies to confirm how well it works to do this, it may … Cholesterol ratio or non-HDL cholesterol: Which is most important? CoQ10 supplementation may also function as a natural aid in lowering cholesterol and improving heart health. Statins are a group of medications that are used to lower high blood levels … The power of a plant-based diet for heart health. Niacin to boost your HDL, 'good,' cholesterol, Nuts and your heart: Eating nuts for heart health. Understanding the Cholesterol Ratio: What It Is and Why It’s Important. Plus, no obvious differences were found between the lengths of therapies. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. In one small study, 50 patients taking statin medications were given 100 mg of CoQ10 or a placebo for 30 days. High cholesterol treatment: Does cinnamon lower cholesterol? Statin muscle-related adverse events. Heart conditions. In the meta‐analysis performed by Banach et al,16only 6 studies with 302 patients were included, and no beneficial effect of CoQ10 supplementation on statin‐induced myopathy was documented, which might be attributed to the limited number of enrolled studies and their small sample sizes. CoQ10 … Cholesterol ratio can give you additional information about your heart disease risk. However, regular CoQ10 is fat-soluble, so it is best absorbed with foods that contain fats. From that time on, it appears that even a great excess of supplemental CoQ10 cannot reverse the damage. Cholesterol: Top foods to improve your numbers, Cholesterol-lowering supplements may be helpful. On the other hand, CoQ10 and fish oil may offer particular benefits to people on statin drugs. Though still controversial, some preliminary evidence suggests that CoQ10 may help to prevent or treat the adverse effects, such as muscle pains and liver problems, of taking statin-type cholesterol drugs. CoQ10 and Statins Statin drugs (Lipitor®, Zocor®, Pravachol®, Crestor®, and the like) are prescribed to lower a person's cholesterol level. Qu H, et al. Having high cholesterol increases your risk for the number one cause of death in the United States -- heart disease. Another review, published in Atherosclerosis, suggests that CoQ10 might improve the health of blood vessels in people with or without heart disease. Healthline Media does not provide medical advice, diagnosis, or treatment. Researchers say an extremely high level of HDL cholesterol can put a person at higher risk of death than someone with normal ‘good’ cholesterol. Rosenson RS, et al. Coenzyme Q10 is a vital nutrient for energy production in cells, especially muscle and heart cells, and coenzyme Q10 deficiency may account for some of the muscle-related … This systematic review and meta-analysis was aimed to determine the effects of coenzyme Q10 (CoQ10) supplementation on lipid profile, as one of the major triggers for CAD, among patients diagnosed with coronary artery disease. While Ubiquinol can serve similar … Our general interest e-newsletter keeps you up to date on a wide variety of health topics. However, it’s a bit of a double-edged sword. Uses; Warnings; Before taking ; Dosage; Overdose; What to avoid; Side effects; Interactions; What is ubiquinone? CoQ10 has been shown to improve symptoms of congestive heart failure. Neurotherapeutics. It can also be found in whole grains. Fasting diet: Can it improve my heart health? Along with these effects, statins also lower your body’s levels of coenzyme Q10. Accessed Oct. 9, 2019. Addition of omega-3 fatty acid and coenzyme Q10 to statin therapy in patients with combine dyslipidemia. So, what exactly is the connection between COQ10 and statins? Ubiquinone is … © 2005-2021 Healthline Media a Red Ventures Company. Methods: EMBASE, Scopus, PubMed, Cochrane Library, and Web of Science were searched for studies prior to May 20th, 2018. However, not all research is positive. Can You Lower Your ‘Bad’ Cholesterol Too Much? More information is needed about the cause of statin-induced myopathy including about how exogenous CoQ10 affects endogenous tissue levels and whether restoring these levels results in a clinical reduction of muscle symptoms. FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online, Can coenzyme Q10 prevent statin side effects, Advertising and sponsorship opportunities. J Basic Clin Physiol Pharmacol. Coenzyme Q10 is a substance the body makes naturally. Preliminary studies have shown that CoQ10 may slow, but not stop, the progression of Alzheimer's disease. Although findings are mixed, CoQ10 might help reduce blood pressure. Coenzyme Q10 (CoQ10): In depth. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Coenzyme Q10 supplements have few reported side effects. The most common seems to be stomach upset. A man-made form of CoQ10 is available as a supplement in most pharmacies and health food stores. If you're on any cholesterol-lowering statin medications such as atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), rosuvastatin (Crestor), and simvastatin (Zocor) we urge you to speak with you're physician immediately to see if supplementation of COQ10 is advisable. CoQ10 supplementation may also function as a natural aid in lowering cholesterol and improving heart health. 2018; doi:10.1161/JAHA.118.009835. At this time, coenzyme Q10 isn't universally recommended for preventing side effects from cholesterol-lowering drugs known as statins. Taylor BA, et al. They do this by inhibiting the body's internal production of cholesterol (they do not affect the cholesterol that you eat). Taking CoQ10 supplements can help increase your CoQ10 levels and may reduce statin side effects. This is an immediate and, it seems, irreversible process. Debra Sullivan, Ph.D., MSN, R.N., CNE, COI, Both Red and White Meat Raise Cholesterol Levels, Study Finds. A single copy of these materials may be reprinted for noncommercial personal use only. Reduced CoQ10 levels can lead to mitochondrial dysfunction, which can cause muscle pain, or myopathy. HDL cholesterol: How to boost your 'good' cholesterol, Healthy heart for life: Avoiding heart disease. Grapefruit does contain compounds that alter … Toth S, Sajty M, Pekarova T, et al. In the present meta‐analysis, 6 newly published RCT studies were included, and the effect of CoQ10 supplementation on statin‐induced myopathy in 12 RCTs with 575 patients was comprehensively evaluated. The combination of CoQ10 and ET resulted in higher plasma CoQ10 levels and more pronounced effects on all the above-mentioned parameters. Is there a risk of rhabdomyolysis from statins? The total amount of CoQ10 in the adult body is about 2 grams, and about 500 mg of that needs to be replaced every day. Our website services, content, and products are for informational purposes only. In a study published in the American Journal of Cardiology, researchers indicate that using CoQ10 supplements seemed to decrease the muscle breakdown, pain, and discomfort of people taking statins. Journal of the American Heart Association. This study adds to the growing body of…. Ubiquinol is the only form of CoQ10 that exists as an antioxidant. Learn what your numbers mean and how to use them to tailor your…. If you’re taking statins and have unpleasant side effects, discuss CoQ10 supplements with your doctor. Low-density lipoproteins (LDL) and very low-density lipoproteins (VLDL) are two types…, HDL is like a vacuum cleaner for cholesterol in the body, as it removes extra cholesterol and plaque buildup in your arteries. Statin Medication Use. As the levels drop, the side effects of statins increase. Wilson's syndrome: An accepted medical diagnosis? In turn, this can cause severe kidney problems. 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